Santa Cruz, is the primary tourist neighborhood of Seville, Spain, and the former Jewish quarter of the medieval city.
Santa Cruz is bordered by the Jardines de Murillo, the Real Alcázar, Calle Mateos Gago, and Calle Santa María La Blanca/San José.
The church in Mudéjar style was constructed over the ruins of a synagogue, incorporating the floor of that older building.
During the Napoleonic Wars the church was demolished as part of an urban renewal scheme, the old floor remained as the present plaza.
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The Plaza de Santa Cruz, on the site of an old parish church and an older synagogue, has at its center an elaborate 17th century wrought iron cross, the Cruz de la Cerrajería ("Locksmith's Cross").